Body Size and Bladder Cancer Risk: A Pooled Analysis of Prospective Studies From the National Cancer Institute Cohort Consortium

Abstract

PURPOSE – Body size is an established risk factor for several cancers, but associations with bladder cancer risk remain unclear.METHODS – We pooled data from 2, 533, 008 participants in 30 international cohort studies to assess associations of BMI, waist circumference, and height with bladder cancer risk. Multivariable Cox regression models, including smoking status, duration, and other confounders, were run separately by cohort and sex, and results combined by random-effects meta-analysis.RESULTS – Incident first primary bladder cancer was diagnosed in 15, 259 males and 5, 188 females. For males, overweight (BMI, 25.0-29.9 kg/m2) and obesity (BMI, ≥30 kg/m2) were associated with increased r..